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71.
Dali Wang Chunlai Tu Yue Su Chuan Zhang Udo Greiser Xinyuan Zhu Deyue Yan Wenxin Wang 《Chemical science》2015,6(7):3775-3787
Despite of great advances of phospholipids and liposomes in clinical therapy, very limited success has been achieved in the preparation of smart phospholipids and controlled-release liposomes for in vivo drug delivery and clinical trials. Here we report a supramolecular approach to synthesize novel supramolecularly engineered phospholipids based on complementary hydrogen bonding of nucleosides, which greatly reduces the need of tedious chemical synthesis, including reducing the strict requirements for multistep chemical reactions, and the purification of the intermediates and the amount of waste generated relative more traditional approaches. These upgraded phospholipids self-assemble into liposome-like bilayer structures in aqueous solution, exhibiting fast stimuli-responsive ability due to the hydrogen bonding connection. In vitro and in vivo evaluations show the resulted supramolecular liposomes from nucleoside phospholipids could effectively transport drug into tumor tissue, rapidly enter tumor cells, and controllably release their payload in response to an intracellular acidic environment, thus resulting in a much higher antitumor activity than conventional liposomes. The present supramolecularly engineered phospholipids represent an important evolution in comparison to conventional covalent-bonded phospholipid systems. 相似文献
72.
73.
The DNA structure is an ideal building block for the construction of functional nano-objects. In this direction, metal coordinating base pairs (ligandosides) are an appealing tool for the future specific functionalization of such nano-objects. We present here a study, in which we combine the metal ion coordinating pyrazole ligandoside with the interstrand crosslinking salen ligandoside system. We show that both ligandosides, when combined, are able to create stable multi-copper ion complexing DNA double helix structures in a cooperative fashion. 相似文献
74.
Qiu‐Ying Huang Ming‐Yang Su Xiang‐Ru Meng 《Acta Crystallographica. Section C, Structural Chemistry》2015,71(6):474-478
The combination of N‐heterocyclic and multicarboxylate ligands is a good choice for the construction of metal–organic frameworks. In the title coordination polymer, poly[bis{μ2‐1‐[(1H‐benzimidazol‐2‐yl)methyl]‐1H‐tetrazole‐κ2N3:N4}(μ4‐butanedioato‐κ4O1:O1′:O4:O4′)(μ2‐butanedioato‐κ2O1:O4)dicadmium], [Cd(C4H4O4)(C9H8N6)]n, each CdII ion exhibits an irregular octahedral CdO4N2 coordination geometry and is coordinated by four O atoms from three carboxylate groups of three succinate (butanedioate) ligands and two N atoms from two 1‐[(1H‐benzimidazol‐2‐yl)methyl]‐1H‐tetrazole (bimt) ligands. CdII ions are connected by two kinds of crystallographically independent succinate ligands to generate a two‐dimensional layered structure with bimt ligands located on each side of the layer. Adjacent layers are further connected by hydrogen bonding, leading to a three‐dimensional supramolecular architecture in the solid state. Thermogravimetric analysis of the title polymer shows that it is stable up to 529 K and then loses weight from 529 to 918 K, corresponding to the decomposition of the bimt ligands and succinate groups. The polymer exhibits a strong fluorescence emission in the solid state at room temperature. 相似文献
75.
Shoutian Qiu Zhiqiang Su Zhaobin Qiu 《Journal of Thermal Analysis and Calorimetry》2017,129(2):801-808
In this work, the isothermal and nonisothermal crystallization kinetics of three novel biobased poly(ethylene succinate-co-ethylene sebacate) (PESSe) copolymers was systematically investigated with differential scanning calorimetry under different crystallization conditions from the amorphous state. For the isothermal cold crystallization kinetics study, the Avrami equation could well describe the crystallization process of PESSe at various crystallization temperatures. All three PESSe copolymers crystallized through the same crystallization mechanism; moreover, the overall isothermal cold crystallization rate of PESSe decreased with increasing ethylene sebacate (ESe) comonomer content. The nonisothermal cold crystallization kinetics of PESSe was also studied at different heating rates. With increasing ESe content or heating rate, the nonisothermal cold crystallization exotherm of PESSe copolymers shifted to high temperature range. Both the crystallization rate parameter and crystallization rate coefficient of PESSe copolymers decreased with increasing ESe content, indicating that PESSe copolymer with higher ESe content crystallized more slowly than that with lower ESe content. The Ozawa equation was used to analyze the nonisothermal cold crystallization kinetics of PESSe copolymers, which was found to fit the crystallization process very well. 相似文献
76.
Yuanfan Wang Jie Chen Dr. Jie Yang Prof. Zhiwei Jiao Prof. Cheng-Yong Su 《Angewandte Chemie (International ed. in English)》2023,62(25):e202303288
A visible light photosensitizing metal-organic cage is applied as an artificial supramolecular reactor to control the reaction of aryl radicals with terminal olefins under green light/solvent conditions, which facilitates selective transformation in the confined enzyme-mimicking environment to give a series of geometrically defined E/Z-alkenes. The hydrophobic cage displays good host–guest inclusion with aromatic substrates, promoting Meerwein arylation and protecting E-isomeric products during reaction; while a small amount of benzonitrile can turn on efficient E→Z isomerization. Besides π–π stacking, the hydrogen bonding and halogen bonding interactions also act as control forces for the arylation of aliphatic terminal olefins known as poor acceptors in classic Meerwein arylation. The application of this switchable cage-confined arylation catalysis has been demonstrated by the syntheses of Tapinarof and a marine natural product from the same substrate via controllable E/Z selectivity. 相似文献
77.
Pei Chen Xi Su Chuanzhe Wang Dr. Guang Zhang Dr. Ting Zhang Prof. Gang Xu Prof. Long Chen 《Angewandte Chemie (International ed. in English)》2023,62(40):e202306224
The emergence of two-dimensional conjugated metal–organic frameworks (2D c-MOFs) with pronounced electrical properties (e.g., high conductivity) has provided a novel platform for efficient energy storage, sensing, and electrocatalysis. Nevertheless, the limited availability of suitable ligands restricts the number of available types of 2D c-MOFs, especially those with large pore apertures and high surface areas are rare. Herein, we develop two new 2D c-MOFs (HIOTP-M, M=Ni, Cu) employing a large p-π conjugated ligand of hexaamino-triphenyleno[2,3-b:6,7-b′:10,11-b′′]tris[1,4]benzodioxin (HAOTP). Among the reported 2D c-MOFs, HIOTP-Ni exhibits the largest pore size of 3.3 nm and one of the highest surface areas (up to 1300 m2 g−1). As an exemplary application, HIOTP-Ni has been used as a chemiresistive sensing material and displays high selective response (405 %) and a rapid response (1.69 min) towards 10 ppm NO2 gas. This work demonstrates significant correlation linking the pore aperture of 2D c-MOFs to their sensing performance. 相似文献
78.
Xingxing Zhang Qingmei Su Gaohui Du Bingshe Xu Shun Wang Zhuo Chen Liming Wang Wenhuan Huang Huan Pang 《Angewandte Chemie (International ed. in English)》2023,62(39):e202304947
Pursuing high power density lithium metal battery with high safety is essential for developing next-generation energy-storage devices, but uncontrollable electrolyte degradation and the consequence formed unstable solid-electrolyte interface (SEI) make the task really challenging. Herein, an ionic liquid (IL) confined MOF/Polymer 3D-porous membrane was constructed for boosting in situ electrochemical transformations of Janus-heterarchical LiF/Li3N-rich SEI films on the nanofibers. Such a 3D-Janus SEI-incorporated into the separator offers fast Li+ transport routes, showing superior room-temperature ionic conductivity of 8.17×10−4 S cm−1 and Li+ transfer number of 0.82. The cryo-TEM was employed to visually monitor the in situ formed LiF and Li3N nanocrystals in SEI and the deposition of Li dendrites, which is greatly benefit to the theoretical simulation and kinetic analysis of the structural evolution during the battery charge and discharge process. In particular, this membrane with high thermal stability and mechanical strength used in solid-state Li||LiFePO4 and Li||NCM-811 full cells and even in pouch cells showed enhanced rate-performance and ultra-long life spans. 相似文献
79.
Jiahui Xian Suisheng Li Hui Su Peisen Liao Shihan Wang Runan Xiang Yawei Zhang Prof. Qinghua Liu Prof. Guangqin Li 《Angewandte Chemie (International ed. in English)》2023,62(30):e202306726
The conversion of industrial exhaust gases of nitrogen oxides into high-value products is significantly meaningful for global environment and human health. And green synthesis of amino acids is vital for biomedical research and sustainable development of mankind. Herein, we demonstrate an innovative approach for converting nitric oxide (NO) to a series of α-amino acids (over 13 kinds) through electrosynthesis with α-keto acids over self-standing carbon fiber membrane with CoFe alloy. The essential leucine exhibits a high yield of 115.4 μmol h−1 corresponding a Faradaic efficiency of 32.4 %, and gram yield of products can be obtained within 24 hours in lab as well as an ultra-long stability (>240 h) of the membrane catalyst, which could convert NO into NH2OH rapidly attacking α-keto acid and subsequent hydrogenation to form amino acid. In addition, this method is also suitable for other nitrogen sources including gaseous NO2 or liquidus NO3− and NO2−. Therefore, this work not only presents promising prospects for converting nitrogen oxides from exhaust gas and nitrate-laden waste water into high-value products, but also has significant implications for synthetizing amino acids in biomedical and catalytic science. 相似文献
80.
Dr. Meng Lu Shuai-Bing Zhang Ming-Yi Yang Yu-Fei Liu Jia-Peng Liao Pei Huang Dr. Mi Zhang Prof. Shun-Li Li Prof. Zhong-Min Su Prof. Ya-Qian Lan 《Angewandte Chemie (International ed. in English)》2023,62(31):e202307632
In this work, we innovatively assembled two types of traditional photosensitizers, that is pyridine ruthenium/ferrum (Ru(bpy)32+/Fe(bpy)32+) and porphyrin/metalloporphyrin complex (2HPor/ZnPor) by covalent linkage to get a series of dual photosensitizer-based three-dimensional metal-covalent organic frameworks (3D MCOFs), which behaved strong visible light-absorbing ability, efficient electron transfer and suitable band gap for highly efficient photocatalytic hydrogen (H2) evolution. Rubpy-ZnPor COF achieved the highest H2 yield (30 338 μmol g−1 h−1) with apparent quantum efficiency (AQE) of 9.68 %@420 nm, which showed one of the best performances among all reported COF based photocatalysts. Furthermore, the in situ produced H2 was successfully tandem used in the alkyne hydrogenation with ≈99.9 % conversion efficiency. Theoretical calculations reveal that both the two photosensitizer units in MCOFs can be photoexcited and thus contribute optimal photocatalytic activity. This work develops a general strategy and shows the great potential of using multiple photosensitive materials in the field of photocatalysis. 相似文献